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Er questions, in particular, about the prevalence of this lesser known disease. She realized she had another tool at her disposal at mayo: the rochester epidemiology project, an nih-funded database of medical records from patients within olmsted county. "because this database covered an area that was medically isolated — nearly all patients got all their medical care right here — we could find out how many people had new-onset heart failure," she explains, "and then we could look back and ask how many had echoes, and we could see what their heart function had been. " as she plumbed the medical records, she showed that diastolic heart failure was not only a major public health concern, but was becoming increasingly common. What's more, even the milder cases were predictive of death. The work, published in the journal of the american medical association in 1998, quickly changed the landscape for the entire field, says cardiologist barry a. Borlaug, m. floridalighttacklecharters.com/thq-cheap-viagra-rp/ http://nationalityinworldhistory.net/bsh-women-viagra-for-sale-ao/ cheap viagra without prescription usa viagra for sale http://floridalighttacklecharters.com/thq-cheap-generic-viagra-gn/ buy generic viagra viagra without a doctor prescription generic viagra in usa cheap viagra online http://classicmotocrossimages.com/mbs-buy-viagra-online-go/ D. That publication, along with another she published in the journal of the american college of cardiology, has been cited hundreds of times. "her work got people fired up about this condition, as they should be," he says, adding that she showed the disease, prevalent in the elderly, occurs most commonly in women. "she's the kind of doctor who sees something in the clinic and doesn't just say, 'that's interesting. ' she wants to know why. " a link to pulmonary hypertension such was the case a few years later, when dr. Redfield looked through the chart of a patient diagnosed with pulmonary hypertension — high blood pressure in the lungs. Dr. Redfield wondered again whether diastolic heart failure might be involved. Following up on this suspicion with a study of patients in the cardiac catheterization lab, she determined diastolic heart failure to be a cause of pulmonary hypertension and published extensively on the significant connection. "a lot of people are writing about it now, but the whole understanding of this phenomenon was triggered by her observation," dr. Borlaug says. Developing animal models dr. Redfield continued to wonder what it was that defined the disease she was seeing in patients. She headed into the lab to develop the first animal models to simulate diastolic heart failure. She found the disease causes blood vessels and the heart to become scarred, rife with inflexible collagen and potentially other factors, which makes them unable to relax. Using sophisticated techniques, including echocardiographic measurements and minute catheters that can thread into a mouse heart smaller than a pea, she set out to measure pressure and heart volume and to characterize the diseased pumping. "it's a highly technical process, and we didn't know at the start whether we would be able to accomplish it and what pressure-volume analysis would tell us," she acknowledges. "but with these models, we're able to learn about the deficiencies in heart function and then test whether our.
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